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Table 1 Examples showing alignment of mature sequences from miR-15 family members and non-family member with matching seeds

From: Specificity and functionality of microRNA inhibitors

Family member

miRNA name

Mature sequence from 5' to 3' end

Family members with sequence identity in both the seed regiona and the 3' regionb

hsa-miR-15ac

U AGCAGCA CAUA AUGGUU UGUG

  

| | | | | | | | | | | | | | | | | |   

 

hsa-miR-15bc

U AGCAGCA CAUC AUGGUU UACA

Family members with sequence identity in the seed regiona but very limited identity in the 3' regionb

hsa-miR-15ac

U AGCAGCA CAUA AUGGUU UGUG

  

| | | | | | | | | | | |   | | | |

 

hsa-miR-16c

U AGCAGCA CGUA AAUAUU GGCG

Non-family members with sequence identity both in the seed regiona and in the 3' regionb

hsa-miR-15ac

U AGCAGCA CAUA AUGGUU UGUG

  

 | | | | | | | | |   | | | | | | | | 

 

hsa-miR-497d

C AGCAGCA CACU GUGGUU UGU 

  1. aBold and italicised.
  2. bBold.
  3. cMember of the miR-15 family.
  4. dMember of the miR-497 family.