| siRNA | Small molecule |
---|---|---|
Specificity | High, sequence driven | Low-medium, conformation driven |
Potency | Typically pM | Variable |
Number of accessible targets | >>1000 | 500 to 1,000 |
Number of potential leads and backups | >>10 to 100, depending on length of target | <2 to 3 |
Speed to lead molecule | 4 to 8 weeks | 2 to 4 years |
Species crossreactivity | High | Low |
Manufacturing | Common, rapid, scalable methods | Variable, can be complex |