Skip to main content

Table 1 A comparison of various drug discovery attributes of siRNAs and small molecules

From: A status report on RNAi therapeutics

  siRNA Small molecule
Specificity High, sequence driven Low-medium, conformation driven
Potency Typically pM Variable
Number of accessible targets >>1000 500 to 1,000
Number of potential leads and backups >>10 to 100, depending on length of target <2 to 3
Speed to lead molecule 4 to 8 weeks 2 to 4 years
Species crossreactivity High Low
Manufacturing Common, rapid, scalable methods Variable, can be complex