Figure 3
Cooperative repressive influence of PUM1 and miR-410 on least accessible targets. (A) In this test, we compared samples having high levels of PUM1 and miR-410 expression with samples having low expression, and calculated the degree of differential repression for all targets. We found that the set of least accessible targets was significantly differentially repressed compared with other targets (P = 6.9 × 10-4). Note that the expression values of PUM1 and miR-410 are drawn schematically. (B,C) We repeated the test described in (A) but now ignored PUM1 and miR-410, respectively. In each of these tests, the differential repression of the least accessible targets compared with other targets was weaker than in (A) (P values obtained are indicated in the figure). (D) We repeated the test described in (A) for 1,000 randomly drawn subsets instead of the subset of least accessible targets. Each random subset contained the same number of targets as the subset of least accessible targets and was disjoint from it. The differential repression of 999 subsets was less significant than 6.9 × 10-4.