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Table 2 MiRNAs and associated cancer types in selected cancer-miRNA modules.

From: Development of the human cancer microRNA network

Rule# Cancer-miRNA modules
  miRNAs Cancer types (Dysregulation patterns) Clustered miRNAs
1 {miR-100} → {miR-125b} breast(D,D), cervical(D,D), HCC(U,U), lung(D,D), ovary(D,D), pancreas(U,U), uterus(U,U) (miR-100, miR-125b)
2 {miR-125b, let-7a-2} → {miR-21} breast(D,D,U), brain(D,D,U), hematologic(D,D,D), cervical(D,D,U), colon(D,D,U), lung(D,D,U), ovary(D,D,U) (miR-125b, let-7a-2)
3 {miR-125a} → {miR-125b} breast(U,D), brain (D,D), HCC(D,U), hematologic (D,D), lung(D,D), pancreas(U,U), uterus(U,U) -
4 {miR-143} → {miR-21} breast(D,U), brain (D,U), cervical(D,U), colon(D,U), hematologic(D,D), lung(D,U), pancreas(U,U), prostate(D,U), uterus(U,U) -
5 {miR-143, miR-145} → {miR-21, miR-125b} breast(D,D,U,D), colon(D,D,U,D), hematologic(D,D,D,D), lung(D,D,U,D), uterus(U,U,U,U) (miR-143, miR-145)
6 {miR-17-5p, miR-20a} → {miR-143, miR-145} colon(U,U,D,D), lung(U,U,D,D), prostate(U,U,D,D) (miR-17-5p, miR-20a), (miR-143, miR-145)
7 {let-7a-1, let-7d, let-7f-1} → {miR-17-5p} urothelial(D,D,D,U), colon(D,D,D,U), lung(D,D,D,U) (let-7a-1, let-7d, let-7f-1)
8 {miR-101, miR-210} → {let-7a-2} breast(D,U,D), lung(D,U,D), ovary (D,D,D) -
  1. In column 3, D = downregulated and U = upregulated for the corresponding miRNAs mentioned in column 2