Figure 7
Conserved regions of the transforming growth factor-β receptor 2 (TGFBR2) untranslated region (UTR) were greatly enriched for small interfering (si)RNA hit target sites. (A) Top: Moving average (window size = 50) of the fraction hit siRNA seed sequences with a heptamer match divided by the fraction of non-hit siRNA, showing regions enriched for hit siRNA seed matches along the 3' UTR of TGFBR2. (B) The vertebrate conservation plot (phastCons 17-way alignment score) shows the correlation between conserved regions and regions enriched for siRNA hits (enrichment factor of 9.8 for heptamer matches in conserved regions).