Inhibition of microRNA function by antimiR oligonucleotides

Stenvang, Jan; Petri, Andreas; Lindow, Morten; Obad, Susanna; Kauppinen, Sakari

doi:10.1186/1758-907X-3-1

Silence

Table 2 Therapeutic targeting of selected disease-associated miRNAs in vivo using antimiR oligonucleotides

From: Inhibition of microRNA function by antimiR oligonucleotides

miRNA	Model	antimiR chemistry	Administration route	Phenotype	Reference
miR-122	Chow-fed mice	Cholesterol-conjugated 2'-O-Me antagomir	i.v.	Lowering of serum cholesterol	[104]
miR-122	DIO mice	2'-MOE	i.p.	Lowering of serum cholesterol	[106]
miR-122	Chow-fed mice	LNA	i.v.	Lowering of serum cholesterol	[96]
miR-122	DIO mice, African green monkeys	LNA	i.p., i.v.	Lowering of serum cholesterol	[90]
miR-122	HCV-infected chimpanzees	LNA	i.v.	Suppression of viremia	[107]
miR-10b	Mouse mammary tumor model	Cholesterol-conjugated 2'-O-Me antagomir	i.v.	Suppression of lung metastases	[123]
miR-132	Orthotopic mouse model of human breast carcinoma	2'-O-Me	Vessel-targeted nanoparticle delivery i.v.	Reduction of angiogenesis and tumor burden	[124]
miR-199b	Mouse model of heart failure	Cholesterol-conjugated 2'-O-Me antagomir	i.p.	Inhibition and reversal of cardiac hypertrophy and fibrosis	[125]
miR-328	Mouse model of atrial fibrillation	Cholesterol-conjugated 2'-O-Me antagomir	i.v.	Normalization of atrial fibrillation	[126]
miR-21	Mouse model of lupus	LNA	i.v., i.p.	Amelioration of autoimmune splenomegaly	[115]
miR-17-5p	Mouse xenograft model of neuroblastoma	Cholesterol-conjugated 2'-O-Me antagomir	Intratumoral injection	Inhibition of tumor growth	[127]
miR-103/107	DIO and ob/ob mice	Cholesterol-conjugated 2'-O-Me antagomir	i.v.	Improved glucose homeostasis and insulin sensitivity	[128]
miR-138	NOD/SCID mice with hydroxyapatixe implants	LNA	ex vivo	Enhanced bone formation	[101]
miR-33	Ldlr^-/- mice	2'-F/MOE	s.c.	Increased serum HDL-C levels, regression of atherosclerosis	[108]
miR-33	DIO mice	LNA	i.v.	Increased serum HDL-C levels	[11]
miR-33	Chow-fed mice	n.d.	i.v.	Increased serum HDL-C levels	[129]
miR-380-5p	Orthotopic mouse model of neuroblastoma	LNA, 2'-F/MOE	i.p.	Decreased tumor growth	[130]
miR-182	Mouse model of arthritis	LNA	ex vivo	Amelioration of arthritis	[54]
miR-29c	db/db mice	2'-O-Me	i.p.	Reduced albuminuria and kidney mesangial matrix accumulation	[131]
miR-208a	Hypertensive rats	LNA	i.v.	Improved cardiac function and survival during heart failure	[102]

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