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Figure 2 | Silence

Figure 2

From: Target gene expression levels and competition between transfected and endogenous microRNAs are strong confounding factors in microRNA high-throughput experiments

Figure 2

Endogenous miRNAs tend to target genes with long 3' UTRs and exogenous miRNAs target highly expressed genes that had a small influence of endogenous miRNAs. Two cumulative density plots of the log-ratio values show the miRNA down-regulatory effects on sub-groups of (A) 3' UTR length with the Grimson dataset and (B) mRNA expression level with the Jackson dataset for ectopically expressed miRNA or siRNA target genes that were separated into T +Endo (T +E), T -Endo (T -E), NT +Endo (NT + E), and NT -Endo (NT -E). miRNA, microRNA; mRNA, messenger RNA; siRNA, small interfering RNA; UTR, untranslated region.

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