Skip to main content

Table 2 PAR-CLIP data show that endogenous miRNA tend to target mRNAs with long 3' UTR

From: Target gene expression levels and competition between transfected and endogenous microRNAs are strong confounding factors in microRNA high-throughput experiments

 

Very Long

Long

Med Long

Med Short

Short

AllRef

917

6194

6201

6198

6201

AGO1

787 (85.82%)

3757 (60.66%)

2371 (38.24%)

1123 (18.12%)

471 (7.60%)

AGO2

320 (34.90%)

1010 (16.31%)

428 (6.90%)

148 (2.39%)

64 (1.03%)

AGO3

883 (96.29%)

4800 (77.49%)

3332 (53.73%)

1804 (29.11%)

639 (10.30%)

AGO4

713 (77.75%)

3087 (49.84%)

1510 (24.35%)

639 (10.31%)

167 (2.69%)

  1. The table shows the total number of genes (AllRef) and the number of Argonaute-bound 3' UTRs (AGO1-4) for each sub-group defined by 3' UTR length (see Methods). Values in brackets indicate the percentage of all genes in the sub-group that have AGO binding sites. miRNA, microRNA; mRNA, messenger RNA; PAR-CLIP, Photoactivatable-Ribonucleoside-Enhanced Crosslinking and Immunoprecipitation; UTR, untranslated region.