Figure 2

Distribution of target overlaps between 5′/3′ microRNA pairs. Average overlap of target predictions for multiple algorithms (grey boxes) and expected overlap based on random sampling (white boxes). Error bars depict standard errors of the means. Statistical differences between distributions underlying the plotted data were assessed by one-tailed Kolmogorov-Smirnov tests with Bonferroni correction. Only P-values below 0.05 are shown. (A) Overlap between lists of targeted genes from microRNA pairs from the same precursor. The human datasets include additional values for strict sets of predictions for four of the algorithms. (B) Term overlap between the targets of 5′/3′ pairs of microRNAs. Human term overlap values were calculated, when available, for the strict target prediction sets.