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Table 1 Effect of arm usage bias on gene overlap of miRanda predictions of 5 /3 microRNA pairs

From: MicroRNAs from the same precursor have different targeting properties

  

Low or no arm usage bias

High arm usage biasb

Drosophila

 

Observed (SEM)

0.1026 (0.0179)

0.0823 (0.0122)

 

Expected (SEM)

0.0840 (0.0011)

0.0706 (0.0009)

 

P-value a (N)

0.183 (62)

0.422 (96)

Human

 

Observed (SEM)

0.3444 (0.0248)

0.3143 (0.0214)

 

Expected (SEM)

0.2906 (0.0021)

0.3104 (0.0019)

 

P-value a (N)

0.059 (87)

0.5369 (70)

Human (strict set)

 

Observed (SEM)

0.0769 (0.0152)

0.0361 (0.0846)

 

Expected (SEM)

0.0464 (0.0012)

0.0430 (0.0011)

 

P-value a (N)

0.028 (87)

0.269 (70)

  1. aP-values for differences between the expected and observed distributions calculated with one-tailed Kolmogorov-Smirnov non-parametric test. bHigh arm usage bias microRNAs defined as those with a ratio of reads mapping to each arm of at least 10:1. SEM: standard error of the mean.