Figure 3
From: cWords - systematic microRNA regulatory motif discovery from mRNA expression data
Modified and unmodified siRNA off-target effects. cWords word cluster plots showing 6, 7, and 8mer words enriched in 3′UTRs of genes downregulated by siRNA off-target binding after transfection of an unmodified (B) and 2-O-methyl modified (C) siRNA targeting Pik3ca. Enrichment of the 6mer seed (bases 2–7, AAAGCC) of the siRNA is highlighted in bold letters and seed region is illustrated in panel (A).