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  1. Review

    A status report on RNAi therapeutics

    Fire and Mello initiated the current explosion of interest in RNA interference (RNAi) biology with their seminal work in Caenorhabditis elegans. These observations were closely followed by the demonstration of RN...

    Akshay K Vaishnaw, Jared Gollob, Christina Gamba-Vitalo, Renta Hutabarat, Dinah Sah, Rachel Meyers, Tony de Fougerolles and John Maraganore

    Silence 2010 1:14

    Published on: 8 July 2010

  2. Meeting report

    RNA silencing in plants: Flash report!

    Earlier this year plant scientists met in Santa Fe, New Mexico at the Keystone Symposium "RNA Silencing Mechanisms in Plants". Sessions included small RNA biogenesis and signalling, development and stress resp...

    Rebecca A Mosher, Mathew G Lewsey and Padubidri V Shivaprasad

    Silence 2010 1:13

    Published on: 30 June 2010

  3. Commentary

    How do miRNAs mediate translational repression?

    Micro(mi)RNAs regulate gene expression by what are believed to be related but separate mechanistic processes. The relative contribution that each process plays, their mechanistic overlap, and the degree by whi...

    Shuo Gu and Mark A Kay

    Silence 2010 1:11

    Published on: 7 May 2010

  4. Research

    Specificity and functionality of microRNA inhibitors

    Micro(mi)RNAs regulate gene expression through translational attenuation and messenger (m)RNA degradation, and are associated with differentiation, homeostasis and disease. Natural miRNA target recognition is ...

    Barbara Robertson, Andrew B Dalby, Jon Karpilow, Anastasia Khvorova, Devin Leake and Annaleen Vermeulen

    Silence 2010 1:10

    Published on: 1 April 2010

  5. Review

    Riding in silence: a little snowboarding, a lot of small RNAs

    The recent symposium, RNA silencing: Mechanism, Biology and Applications, organized by Phillip D. Zamore (University of Massachusetts Medical School) and Beverly Davidson (University of Iowa), and held in Keyston...

    Stefan L Ameres and Ryuya Fukunaga

    Silence 2010 1:8

    Published on: 15 March 2010

  6. Short report

    microRNA as a new immune-regulatory agent in breast milk

    Breast milk is a complex liquid that provides nutrition to the infant and facilitates the maturation of the infant's immune system. Recent studies indicated that microRNA (miRNA) exists in human body fluid. Be...

    Nobuyoshi Kosaka, Hirohisa Izumi, Kazunori Sekine and Takahiro Ochiya

    Silence 2010 1:7

    Published on: 1 March 2010

  7. Research

    Development of the human cancer microRNA network

    MicroRNAs are a class of small noncoding RNAs that are abnormally expressed in different cancer cells. Molecular signature of miRNAs in different malignancies suggests that these are not only actively involved...

    Sanghamitra Bandyopadhyay, Ramkrishna Mitra, Ujjwal Maulik and Michael Q Zhang

    Silence 2010 1:6

    Published on: 2 February 2010

  8. Review

    Aptamer-targeted cell-specific RNA interference

    This potent ability of small interfering (si)RNAs to inhibit the expression of complementary RNA transcripts is being exploited as a new class of therapeutics for a variety of diseases. However, the efficient ...

    Jiehua Zhou and John J Rossi

    Silence 2010 1:4

    Published on: 1 February 2010

  9. Research

    Expression patterns of intronic microRNAs in Caenorhabditis elegans

    MicroRNAs (miRNA) are an abundant and ubiquitous class of small RNAs that play prominent roles in gene regulation. A significant fraction of miRNA genes reside in the introns of the host genes in the same orie...

    Meltem Isik, Hendrik C Korswagen and Eugene Berezikov

    Silence 2010 1:5

    Published on: 1 February 2010

  10. Review

    How to slice: snapshots of Argonaute in action

    Argonaute is the principal protein component of the mechanisms of RNA silencing, providing anchor sites for the small guide RNA strand and the 'slicer' activity for cleavage of target mRNAs or short passenger ...

    James S Parker

    Silence 2010 1:3

    Published on: 12 January 2010

  11. Research

    Solution structure of the Drosha double-stranded RNA-binding domain

    Drosha is a nuclear RNase III enzyme that initiates processing of regulatory microRNA. Together with partner protein DiGeorge syndrome critical region 8 (DGCR8), it forms the Microprocessor complex, which clea...

    Geoffrey A Mueller, Matthew T Miller, Eugene F DeRose, Mahua Ghosh, Robert E London and Traci M Tanaka Hall

    Silence 2010 1:2

    Published on: 12 January 2010

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